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Antabuse

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By: Leonard S. Lilly, MD

bulletProfessor of Medicine, Harvard Medical School, Chief, Brigham and Women's/Faulkner Cardiology, Brigham and Women's Hospital, Boston, Massachusetts

https://connects.catalyst.harvard.edu/Profiles/display/Person/26967

If you cannot expose the urethra medicine and manicures generic 250 mg antabuse with visa, especially in an elderly woman with atrophy of the vagina medicine 2410 250 mg antabuse mastercard, mount a Ch16 catheter on an introducer treatment quadriceps pain buy 500mg antabuse with mastercard, and gently pass this along the anterior wall of the vagina till it drops effortlessly into the bladder medications in carry on luggage buy cheap antabuse 250mg. You may need to palpate the urethral orifice with a finger and guide the introducer accordingly. Try irrigating the catheter with sterile water, and if this fails, change the catheter. If the catheter blocks, especially with clot after prostatectomy, this is usually because of inadequate irrigation. Try to dislodge the clot by instilling heparinised water with a bladder syringe, and sucking out the bloody urine and clots. If this does not work and water can be instilled but not withdrawn, thus making the patient more and more uncomfortable, deflate the catheter balloon and push the catheter in, wriggling it about; this might cause the clot in the eye of the catheter to dislodge. If the catheter balloon will not deflate, cut the catheter across, and leave it for 6hrs to empty. Wash out the bladder with 200ml sterile water, to remove the oil and any balloon fragments which may have been left behind. Alternatively, palpate the balloon per rectum, and direct a needle guided by your finger to burst it: this is potentially hazardous, so wear thick gloves and administer gentamicin! If you have ultrasound, it is easy to guide a needle into the balloon suprapubically to rupture it. If not, you can pass a well-lubricated catheter introducer through the urine drainage channel and thereby push the end of the catheter up against the anterior abdominal wall: when the balloon is palpable or visible, rupture it with a needle. If you cannot remove an indwelling catheter, even though you have deflated the balloon, you have probably left it in much too long, so that crusts have anchored it to the mucosa. If you pull it out firmly, you will damage the mucosa and may rupture the urethra. You may have to open the bladder to remove the catheter; if the reason the patient has a catheter in the first place is prostatic enlargement, use this opportunity to perform a prostatectomy (27. If you have inflated the balloon in the urethra, deflate it and remove the catheter; do not attempt re-catheterization via the urethra. If the balloon will not deflate, palpate it through the penoscrotal skin, and rupture it with a needle. For this you only need the simplest instrument, without provision for catheterizing the ureters. Cystoscopy is an acquired skill, even with equipment using a fibre-optic light source rather than a solid rod lens system. If it is still misty, water has probably entered the telescope, so return it to the makers or an agent for repair. If this only happens after you have inserted the sheath, it is the sheath which is bent. Even though you may be able to put your cystoscope (if it is an old-fashioned sort) in an autoclave, it will last longer if you use an antiseptic solution. Remove the compression ring and valve, and immerse it in glutaraldehyde solution, 1% chlorhexidine, 1/1000 mercury oxycyanide, or 1/80 phenol for 10mins; immersion will kill all bacteria capable of infecting the bladder. You may be able to examine a woman as an outpatient without any anaesthesia if you are gentle and use a lubricated instrument, unless she has a painful stricture of her external meatus, or a very irritable bladder. The urethroscope has 0є viewing angle (to look straight ahead), and a viewing cystoscope 30-70є (to look around). If the patient has an enlarged prostate, cystoscopy may precipitate acute retention, so do it as the first stage of a prostatectomy (27. Massage the penile urethra, so as to squeeze the jelly into the posterior urethra. Use the semi-lithotomy position: flex the hips to only 75є and abduct them 30-45є, so as to leave the buttocks further up the table than the poles. To provide fluid for irrigation, you can use autoclaved water in a receptacle maximally 60cm above the patient. Introduce the cystoscope into its sheath, and lubricate the outside with petroleum or lidocaine jelly. It is best to start with a 0є urethroscope or 30є cystoscope to visualize the urethra. Clean the glans penis of a man thoroughly under the foreskin and hold the penis vertically with your left hand. Introduce the cystoscope gently into the urethra (27-4C) viewing it directly, and stretch the penis along it, as it descends under its own weight.

Syndromes

bulletHow well the enzyme works in the body
bulletMastectomy is when all breast tissue is removed. Mastectomy is a better choice if the area of cancer is too large to remove without deforming the breast.
bulletStress the benefits of the procedure and talk about things that the child may find pleasurable after the test, such as feeling better or going home. You may want to take your child for ice cream or some other treat afterwards, but do not make this conditional on "being good" for the test.
bulletDo not smoke.
bulletExcess blood loss
bulletGeneral ill feeling
bulletInborn errors of metabolism
bulletStiff neck
bulletSevere neonatal jaundice

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It is one of the few surgical methods which you can usefully practise before you operate on a living human patient symptoms 0f diabetes order antabuse 250mg amex. You will usually anastomose bowel end-to-end medicine 19th century cheap antabuse 500mg with mastercard, but there will be occasions when you will have to symptoms torn meniscus antabuse 500 mg with amex do it end-to-side medicine allergy antabuse 250 mg without a prescription, (as in a Roux loop) or side-to- side (as in a gastroenterostomy, or cholecysto-jejunostomy) Do not be worried by the complexity of the methods which follow. If you bring only the mucosal surfaces together there will be no strength in the join and a leak is likely. Beware of mucosa pouting out after the first layer; it can easily do this at the mesenteric border. Do the suturing outside the abdominal cavity on a towel, or pack away the rest of the abdominal contents. This starts on the ante-mesenteric border to the mesenteric border C, where it turns round to close the anterior layer the bowel and D meets the beginning of the suture again back at the antimesenteric border. Pitfalls: I, bowel closed longitudinally (which will result in stricture formation). J, bowel cut obliquely in a way which reduces the blood supply to an area on the ante-mesenteric border of one loop. L, mesentery bunched together with a suture which occludes the vessels supplying the bowel. Note that any sutures which go right through the wall of the bowel (and so might leak) are usually infolded by a 2nd layer of sutures which go through serosa and muscle only; these are called Lembert sutures. Make the Lembert sutures of the 2nd layer bring the serosa of one loop into contact with the serosa of the other loop. Only put them through the outside peritoneal layer, the muscle, and the submucosa (the strongest layer of the bowel), and do not go through the mucosa into the lumen of either loop. Use a continuous suture: it is easier, cheaper, and probably more reliable than using interrupted sutures, even with large bowel. Avoid catgut: it dissolves just when the bowel is healing, and so needs a 2nd layer of sutures for protection. Crushing clamps have narrower, stiffer blades, a ratchet with fewer teeth, and sometimes interlocking ridges on the blades to grip the bowel more firmly. Crushed bowel dies, so cut the crushed bowel away with the clamp before making an anastomosis. As you do this, be sure there is a non-crushing clamp applied to stop the contents of the bowel spilling out. You will often have to operate on bowel when it is distended and full of intestinal content: this fluid has millions of bacteria, particularly anaerobes. Spillage into the peritoneal cavity will cause septicaemia very quickly because the peritoneal layer is such a good absorptive surface. So, in this situation, you will have to use clamps; however, if you then join bowel which is full of intestinal fluid, this will all have to pass the anastomosis! You will need to make sure that the bowel reaches outside the abdomen, and emptying it does not contaminate the peritoneal cavity, the very thing you want to avoid! Therefore before you empty the bowel, pack away the abdomen as a protective measure. This will not work in the distal small bowel or colon because the content is usually too thick, but that is where it is more important to empty it! You will then have to allow the bowel content to pour out into a bowl, getting an assistant to hold both bowel and bowl carefully so as not to spill the fluid, whilst you milk the content out. You can decompress bowel via a nasogastric tube if the content is very fluid, and your anaesthetist is ready to suck out the contents. The danger is spillage into the mouth, and from there into the lungs, especially if the endotracheal tube is uncuffed: do not use this method therefore with children! Non-crushing clamps have been designed to exert the right pressure without being covered with rubber tubes. For any method of anastomosis the bowel must be viable, which also means that its blood supply must be good enough. Wait to decide if the bowel is viable or not until you have removed the cause (divided an obstructing band, or untwisted bowel which has twisted on its mesentery). Bowel is viable if: (1) its surface is glistening, (2) its colour is pinkish, or only slightly blue, (3) it feels resilient like normal bowel, (4) it contracts sluggishly (like a worm) when you pinch it, (5) you can see pulsations in the vessels which run over the junction between it and its mesentery.

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It is thought that a central nervous system model of body dynamics is essential to symptoms precede an illness discount 500mg antabuse with mastercard anticipatory control of posture during movement (Frank & Earl 1990) section 8 medications discount antabuse 500 mg with mastercard. The postural body schema consists of: alignment of body segments to administering medications 8th edition generic antabuse 500 mg fast delivery each other and in relation to medicine 257 discount antabuse 250mg visa the environment; movement of the body segments in relation to the base of support; orientation of the body in relation to gravity (verticality). The integration of visual, vestibular and somatosensory information is complex and dependent on intact sensory motor networks. It has been suggested that there is a sensory re-weighting of afferent information dependent on different sensory conditions (Oie et al. This allows for a bias towards the most appropriate senses dependent on the task and the environment. The neurological patient will use available senses which will directly affect their postural body schema. This is particularly evident in patients who have diminished somatosensation and may then place a greater reliance on visual and vestibular information. A common problem that may develop is acquired sensory loss due to lack of appropriate use of somatosensory information. Patients with neurological dysfunction often continue to rely heavily on visual information, limiting the integration of somatosensory information. Systems control of posture and movement the complex picture which is exhibited in patients with neurological conditions almost always involves damage to the systems which control posture and voluntary movement. When the descending drive to the spinal cord is disrupted, this leads to problems organising appropriate goal-orientated patterns of activity on a background of postural control. The human body is fundamentally unstable due to the evolvement of bipedal stance to free the upper limbs for function. Maintaining stability requires a finely tuned complex processing of information in order to maintain appropriate postural stability within the many varied postures that are necessary for us to function on a daily basis. Postural responses occur in anticipation of and alongside movement, and during unexpected perturbations, and are commonly known as feed-forward and feedback control, respectively. Intended actions involve motor planning at a higher level, including the cerebellum, basal ganglia and cerebral cortex, and form feed-forward mechanisms to adapt motor and sensory systems on the basis of previous experience. Although postural control and balance activities can be influenced by the cortex, they are regulated by systems in the brainstem. Automatic responses to unexpected perturbations occur on the basis of ongoing visual, vestibular and somatosensory information. Recruitment of appropriate musculature to produce rapid postural control strategies involves medial descending systems, including the vestibulospinal and pontine reticulospinal systems. They act on axial and proximal muscles, and are involved in maintaining an upright posture and integrating movements of the limbs with the trunk. Lateral descending systems, including corticospinal and rubrospinal systems, are responsible for the recruitment of distal muscles and therefore support postural control through the production of selective movement (Ruhland & Le van Kan 2003; Schepens & Drew 2004; Lalonde & Strazielle 2007). In patients with neurological dysfunction, there is usually a bias of systems damage which results in different presentations. A primary problem in many patients is the weakness of neural drive to postural muscles which leads to difficulty producing appropriate antigravity activity for smooth coordinated movement. Muscle weakness and reintegrating afferent information contribute to postural instability in stroke (Marigold et al. This leads to fixation strategies that prevent the patient from developing adaptable movement and limits their movement choices. Requirements of efficient movement Identifying the requirements of efficient movement with respect to function is fundamental to clinical reasoning in the Bobath Concept. Postural control is an essential foundation for movement with the following being key requirements incorporated into postural control for functional movement: Balance strategies Patterns of movement Speed and accuracy Strength and endurance Understanding how these interlink and influence each other is especially important in understanding the complexity of the control of movement for clinical reasoning. There is little argument in the literature regarding the importance of postural control for efficient movement (Pollock et al. It involves the ability to orientate and stabilise the body within the force of gravity using appropriate balance mechanisms. The recovery of balance is a critical component for achieving independence in the activities of daily living (Lundy-Ekman 2002). Analysis of postural alignment is an important feature of the assessment process (Lennon & Ashburn 2000).

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The knee is the most difficult of the three joints on which you may have to medicine - purchase antabuse 250mg with mastercard operate medications major depression purchase 250 mg antabuse otc, especially in an adult red carpet treatment order antabuse 250 mg visa, whose tibia can be rotated backwards and laterally symptoms diarrhea buy antabuse 250mg on line, as well as being flexed. If you try, the tight popliteal vessels and nerves may be stretched; and pain, paralysis, and even gangrene may follow. After you have released it as much as you can by tenotomy, you can obtain the final correction by daily increasing buckle correction. Insert a Steinmann pin through the upper tibia and incorporate this in a long leg cast, with a slit in the popliteal area. Apply traction to the Steinmann pin to avoid posterior subluxation of the knee, and adjust the buckle to give an extra 1mm extension per day (32-16). There may already be remarkable mobility, and although a straight leg may look better, it may not work better, especially if it needs callipers. He may be able to crawl fast and cultivate the fields on the hands and knees, but if he can only walk slowly and stiffly in callipers, he may die of starvation. So a cultivator may be better crawling, especially if his arms are too weak to use crutches, whereas an office worker, for example, may benefit from callipers. The common peroneal (lateral popliteal nerve) descends obliquely along the lateral side of the popliteal fossa to the head of the fibula, close to the medial margin of biceps femoris. It lies between the tendon of biceps femoris and the lateral head of gastrocnemius, and winds round the lateral surface of the neck of the fibula deep to peroneus longus. If you have many patients, start by operating on the younger ones with lesser deformities first. The patient will need crutches, so he must have 2 arms, especially if both legs and the trunk are weak. There are exceptions to this rule, and a really determined adult, or child, sometimes manages surprisingly well with limited weakness in one or both arms, provided the trunk is strong. This includes: (a) a contracture of the hip alone of 30є, especially if it also has a mild abduction deformity, which may increase its stability and compensate for shortening. Scar tissue is not stable for at least 6months, so when you correct contractures, you must find some way of maintaining the position of the limb for at least 6months, or longer, if there is still muscle imbalance, or much scar tissue. Operate under full sterile precautions, and prepare both legs, even if you are only going to operate on one of them. Squeeze all blood out of the incisions periodically during the operation, and at the end. The structures you are going to divide must be tense, as you divide them, so keep the hip in as much extension and adduction as you can, while you cut. Feel the tight structures through the skin, to make sure that you have left no tight bands undivided. Push the knife horizontally into the outer side of the thigh, just behind the tight band, until it just touches the lateral side of the femur. Rotate its blade, so that its cutting edge is upwards; then cut all the subcutaneous structures anterior to the blade, and lateral to the femur. Provided you make the incision in the right place, and only cut anteriorly, you will not cut anything important. Do not cut posteriorly, or you may cut the popliteal artery, or the lateral popliteal nerve. Feel for the tensor fascia lata, and push the knife in along its posterior border down to the bone, exactly as for the first incision. Then rotate the knife 90є and cut anteriorly and laterally to the outer side of the shaft of the femur. If you cannot feel the tensor fascia lata, insert the knife where you think it should be and cut exactly the same way. Do not push the knife further medially than a point 2 cm lateral to the mid-inguinal point (where you can feel the artery). Push the knife in subcutaneously, below the anterior superior iliac spine, from a lateral to a medial direction, so that its flat surface is in the plane of the skin just caudal to the anterior superior iliac spine. Then rotate it 90є, so that its edge faces backwards, and cut all the tight subcutaneous structures. When you have cut the tight structures anteriorly, twist the knife so that it cuts laterally, and cut all the tight structures on the anterolateral side of the hip. Feel them through the skin during the operation, and do not leave any tight deforming bands behind. The method which follows is a very limited open tenotomy suitable for a patient: (1) who needs a bit more extension, so that he can be put into skin traction, (2);whose biceps femoris tendon is tight, but not the semitendinosus and semimembranosus tendons, which are attached medially.

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References:

bullethttp://www.dougbremner.com/SNAP.pdf
bullethttps://sd25.senate.ca.gov/sites/sd25.senate.ca.gov/files/research_booklet_sb_328_pdf.pdf
bullethttps://www.pncb.org/sites/default/files/2017-02/NONPF_Core_Competencies.pdf
bullethttps://images-eu.ssl-images-amazon.com/images/I/D1iRlPgzTkS.pdf